low level laser therapy in management of chemotherapy-induced oral mucositis: prophylaxis or treatment?
نویسندگان
چکیده
introduction: chemotherapy-induced oral mucositis (com) is a common, debilitating complication of cancer therapy. the aims of this study were to evaluate the effect of low level laser therapy (lllt) on prevention of com in patients with hematologic malignancies. methods: fifty-five patients hospitalized to undergo chemotherapy in imam hospital were included into the study. these patients were divided into two groups. the oral cavity of the patients were illuminated by continues laser beam using a gaalas laser device with wavelength of 630 nm, power output 30 mw, and dose of 5 j/cm2 for six days (lllt group). the patients in the second group underwent placebo irradiation (power output equal to zero) with the similar protocol. the severity of the com was clinically evaluated based on who grading scale. the patientys’quality of life was assessed before and after the intervention according to eortc qlq-c30 questionnaire. results: the incidence of com in lllt group (31%) was less than the placebo group (41%). mean duration of com healing was 4.8 and 12 days in lllt and placebo groups, respectively (p=0.03). xereostomia was significantly less severe in lllt group in comparison with the placebo group (p=0.007). conclusion: our findings showed that lllt significantly reduced the incidence of oral mucositis of who grade 3 and 4 as the most debilitating form of oral mucositis,in which oral alimentation is impossible. also, lllt could reduce duration of oral mucositis, decreased the risk of secondary infection, and accelerated return to normal nutrition.
منابع مشابه
Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients.
OBJECTIVE A pilot clinical study was conducted to evaluate the efficacy and feasibility of low-level laser therapy (LLLT) in the prevention and treatment of chemotherapy (CT)-induced oral mucositis (OM) in young patients. BACKGROUND DATA Besides compromising the patient's nutrition and well-being, oral mucositis represents a portal of entry into the body for microorganisms present in the mout...
متن کاملLow level laser therapy (LLLT): a new paradigm in the management of cancer therapy-induced mucositis ?
متن کامل
Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis.
This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the en...
متن کاملRadiation therapy and chemotherapy-induced oral mucositis.
UNLABELLED Increasing the intensity of radiation therapy and chemotherapy in the management of cancer has increased the incidence of adverse effects, especially oral mucositis. AIM AND METHODS a bibliographical review was conducted on the definition of oral mucositis, its clinical findings, the incidence, its etiology, the pathophysiology, associated morbidity, prevention and treatment. RES...
متن کاملPain management for chemotherapy-induced oral mucositis.
The number of children and young people diagnosed with cancer is increasing every year. Pain is a significant side effect of disease, surgery and treatments including chemotherapy. After a course of intensive chemotherapy, some children develop oral mucositis, a debilitating condition causing bleeding, pain and inflammation. Moderate and severe mucositis pain is treated with continued good oral...
متن کاملevaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis.
radiotherapy in the head and neck region and chemotherapy might give rise to oral mucositis which is a severe and painful inflammation. there is no known definite cure for mucositis. a number of studies have attempted to evaluate the effect of low-power laser on radiotherapy- and chemotherapy-induced mucositis. the present study was undertaken to evaluate the effect of low-power laser on the pr...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of lasers in medical sciencesجلد ۲، شماره ۱، صفحات ۱۲-۱۷
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023